1989 Oct 05; 264(28):16957-62. Note that an individual publication can be assigned to more than one field. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. Hepatology. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. 2018 12; 15(12):785. Hepatology. Int J Mol Sci. 2012 Mar; 10(3):285-90.e1. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. Studies with human cultured skin fibroblasts. J Hepatol. 2021; 16(12):e0260721. J Biol Chem. Hepatology. Am J Physiol. Semin Liver Dis. Cell Cycle. Cell Metab. J Immunol. 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From quiescence to activation: Gene regulation in hepatic stellate cells. Methods Enzymol. Neurobiol Aging. What goes up must come down: the emerging role of microRNA in fibrosis. J Clin Exp Hepatol. 2008 Dec; 48(6):2016-26. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Analysis of the collagen alpha 1(I) promoter. 2019 03 29; 10(1):1406. Gastroenterology. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. PLoS One. Reversibility of liver fibrosis. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. La Jolla groups issue letter on city parks master plan. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. Gastroenterology. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. We lose people all of the time. In Vitro Cell Dev Biol. 2004 Jun; 135(6):619-28. Am J Physiol. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. 1998; 8(3-4):283-5. Alcohol Clin Exp Res. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. 1999 Aug; 31(4):305-19. 2015; 10(7):e0129743. Altman Clinical and Translational Research Institute (ACTRI). Best Pract Res Clin Gastroenterol. 2006 Aug; 116(8):2058-9. Am J Epidemiol. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. 2019 Apr 07; 20(7). Gastroenterology. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Toxicol Appl Pharmacol. J Clin Invest. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). 2003 Mar 07; 278(10):8083-90. 1988 Jan-Feb; 8(1):176-82. Antioxid Redox Signal. 2013 Mar; 62(3):335-6. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 1999 Sep 15; 163(6):3474-83. 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Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. 2005 Mar; 39(3):181-8. 2021 03; 18(3):151-166. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Deletion of the ferrochelatase gene in a patient with protoporphyria. Surgery. 2015 Dec; 149(7):1784-93. Mol Cell Biol. 2003 Nov; 285(5):G949-58. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 2010 Oct; 52(4):1420-30. Proc Natl Acad Sci U S A. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Curr Opin Gastroenterol. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. 2011 Aug; 35(8):1509-18. 1994 Sep; 3(9):1695-7. People in Profiles who have published with this person. 2015 Nov; 22(11):1837-45. 2006 Apr; 43(4):872-8. 1998 Sep; 13 Suppl:S39-50. medRxiv. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. 2007 Apr-Jun; 6(2):83-8. 2018 12; 16(12):1974-1982.e7. Aliment Pharmacol Ther. FASEB J. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. 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WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Mol Cell Biol. Nat Clin Pract Gastroenterol Hepatol. NOX in liver fibrosis. Hepatology. 2016 Aug; 38(4):291-302. 2007 Nov; 46(5):1443-52. 2017 09 15; 331:135-141. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Gastroenterology. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. 2017 Apr 03; 127(4):1254-1270. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. 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Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. J Biol Chem. Stroke. 1998 Jul 01; 102(1):107-14. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. Gastroenterology. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. 2016 07; 111(7):986-94. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. 2020 Apr; 4(4):606-626. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. Transplantation. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Gastroenterology. J Bone Miner Res. Am J Physiol Gastrointest Liver Physiol. 2020 12 15; 95(24):e3163-e3179. J Biol Chem. 2001 Dec; 35(6):749-55. 2010 Sep; 139(3):987-98. Hepatology. 2021; 8:790032. 2012 Jul; 36(1):22-9. 1995 Sep 29; 270(39):22689-92. Fibrogenesis Tissue Repair. Nephron. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Expression of collagen genes in the liver. 2008 Mar; 23 Suppl 1:S98-103. New Approaches for Studying Alcoholic Liver Disease. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. 2009 Oct; 137(4):1467-1477.e5. J Neurol. J Clin Gastroenterol. Gastroenterology. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. 2001 Nov; 34(5):953-63. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2001 Sep; 25(9):1360-7. 2006 Apr; 12(4):550-9. 2004 Aug 01; 173(3):1561-70. 2003 Apr; 38(4):468-75. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Fra, Fra away: the complex role of activator protein 1 in liver injury. 1989 Jun 05; 264(16):9583-91. Gastroenterology. Am J Gastroenterol. 2018 06; 67(6):2150-2166. J Clin Immunol. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. 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Exp Neurol. 1996 Nov; 271(5 Pt 1):G780-90. 2005 Dec; 42(6):1320-8. Am J Physiol. Nature. David has 2 jobs listed on their profile. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. 2013 Dec; 58(6):1930-40. 2004 Jun; 40(6):942-51. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. J Exp Med. 2019 01; 49(2):183-193. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. 2018 09; 68(3):918-932. 2000 Apr 21; 275(16):12207-13. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. 2001 Jun; 280(6):G1178-86. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. 2003 Apr 15; 170(8):4053-60. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. 1988 Sep-Oct; 8(5):1040-5. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. 1984; 49:151-60. Am J Hum Genet. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 1998 Sep; 13(S1):S39-S50. Biotechniques. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. 2014 Dec; 26(12):1802-11. 1991; 10(3-4):452-5. 2010 Sep; 139(3):836-45, 845.e1. 2002 Sep; 123(3):877-8. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Mol Cell Biol. J Mol Med (Berl). 2013 Sep 16; 202(6):951-66. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. 1999 Aug; 14(8):1272-80. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Gastroenterology. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. J Immunol. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. 2015 Nov-Dec; 49 Suppl 1:S25-7. Trans Am Clin Climatol Assoc. Is it the end of the line for the EMT? Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Cell Metab. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Gastroenterology. 2007 Nov; 13(11):1324-32. 2019 03; 156(4):1156-1172.e6. 2019 11 05; 30(5):850-852. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 2005 Sep; 289(3):G530-8. Of Mice and Men and Nonalcoholic Steatohepatitis. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. PLoS One. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Mechanisms of liver fibrosis and its role in liver cancer. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 86(7):676-86. Hepatology. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. J Clin Invest. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Proc Natl Acad Sci U S A. Gastroenterology. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. 1998 Sep; 13 Suppl:S93-5. 2019 07; 70(1):127-141. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. 2006 Jul; 131(1):272-5. Cell Metab. Transient induction of c-jun during hepatic regeneration. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. J Hepatobiliary Pancreat Sci. Anti-fibrogenic strategies and the regression of fibrosis. 2005 Sep-Oct; 7(9-10):1346-55. 2002 Dec; 36(6):1498-508. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. On UCSDs portion of the liver without infiltration of neutrophils in tissue and blood protein modulates damage... 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